Brunswick S41i CO2 Incubator-Shaker with the Universal Platform

Eppendorf New Brunswick S41i CO₂ Incubator Shaker: Your Seamless Alternative for Mammalian Suspension Cell Culture

The Eppendorf New Brunswick S41i CO₂ incubator shaker represents a revolutionary alternative to open-air shakers placed inside traditional CO₂ incubators, delivering superior performance specifically engineered for mammalian suspension cell culture applications. This 170-liter integrated system combines advanced CO₂ incubator functionality—including 120°C high-temperature disinfection and a seamless stainless-steel chamber—with Eppendorf's proven heavy-duty Innova triple-eccentric drive mechanism for vibration-free, reliable 24/7 operation. Unlike makeshift solutions that limit flask capacity, restrict vessel formats, increase maintenance demands, and create multiple contamination points, the S41i provides exceptional vessel format flexibility accommodating plates, tubes, and shake flasks up to 5L Corning®/Thomson Ultra Yield® capacity on its universal platform system with interchangeable dedicated platforms.

Engineered for reproducible results and optimal growth conditions, the S41i delivers tight CO₂ specifications with a control range of 0.2-20% (0.1% step size), exceptional accuracy of ±0.2% at 5% CO₂, and remarkable homogeneity of ±0.1%—critical factors for reliable medium pH control. The humidity-independent IR CO₂ sensor with auto-zero function, combined with smart gas control and a protective double-door system, ensures enhanced atmosphere integrity while dramatically reducing CO₂ consumption by up to 14 times compared to competitors. The water tray-based humidification system maintains 95% relative humidity at 37°C, providing effective medium evaporation protection that demonstrates 56% and 62% improvement over evaporator-based steam humidification systems in 96-well plates and 250mL Erlenmeyer flasks respectively. Temperature control spans 4°C above ambient to 50°C with exceptional stability (±0.1°C at 37°C) and uniformity (±0.25°C inside flask liquid).

The S41i's powerful anti-contamination design includes a fan-less chamber that eliminates airborne contaminant circulation, an easy-to-clean seamless stainless-steel interior with rounded corners, easily removable single-piece water trays, and integrated 120°C high-temperature disinfection that heats the chamber for 4 hours to effectively eliminate contaminants. The compact design (87.5 × 73 × 85 cm) fits easily under benches or can be stacked to double capacity within the same footprint, making it ideal for growing labs with limited space. Operating at remarkably quiet 50 dB(A) in steady state and consuming significantly less CO₂ than competitors, the S41i supports sustainability goals while reducing operational costs. The double-door system protects light-sensitive expression media while the intuitive touchscreen interface enables easy operation with or without gloves. Backed by Eppendorf's nearly 80-year legacy of reliability and supported by comprehensive epServices maintenance agreements, the New Brunswick S41i is the reliable choice for expansion of mammalian cell lines (CHO, HEK293), viral vector production, bioreactor inoculum preparation, MSC/iPSC cultivation, and applications requiring both static and shake flask cultivation.

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